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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EPS15
All Species:
13.03
Human Site:
S491
Identified Species:
28.67
UniProt:
P42566
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42566
NP_001153441.1
896
98656
S491
D
S
Q
Q
E
I
S
S
M
Q
M
K
L
M
E
Chimpanzee
Pan troglodytes
XP_001139393
896
98643
S491
D
S
Q
Q
E
I
S
S
M
Q
M
K
L
M
E
Rhesus Macaque
Macaca mulatta
XP_001113811
1015
110551
Q619
R
L
Q
Q
E
E
T
Q
L
E
Q
S
I
Q
A
Dog
Lupus familis
XP_532580
889
97932
S478
D
S
Q
Q
E
I
S
S
M
Q
M
K
L
M
E
Cat
Felis silvestris
Mouse
Mus musculus
P42567
897
98453
S491
E
S
Q
Q
E
I
S
S
M
Q
M
R
L
E
M
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001026454
920
100691
P513
S
G
K
A
Q
L
G
P
L
Q
Q
H
L
Q
D
Frog
Xenopus laevis
O42287
1270
143652
H524
L
R
I
A
E
I
T
H
L
Q
Q
Q
L
Q
E
Zebra Danio
Brachydanio rerio
XP_002663145
1039
114340
Q524
E
S
H
T
Q
I
V
Q
E
Q
E
R
L
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001122937
1043
116535
Q530
D
T
Q
L
Q
I
C
Q
A
K
A
K
I
T
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001192039
1179
125310
E640
Q
T
N
Q
E
I
T
E
L
H
T
K
L
S
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P34216
1381
150765
N762
L
N
Q
V
T
V
A
N
L
Q
K
E
I
D
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
43.2
91.5
N.A.
89.3
N.A.
N.A.
N.A.
74.6
21
50.5
N.A.
N.A.
30.1
N.A.
29.6
Protein Similarity:
100
99.7
59.5
94.5
N.A.
93.4
N.A.
N.A.
N.A.
84.1
34.9
64.4
N.A.
N.A.
48.2
N.A.
44.3
P-Site Identity:
100
100
20
100
N.A.
73.3
N.A.
N.A.
N.A.
13.3
33.3
33.3
N.A.
N.A.
26.6
N.A.
33.3
P-Site Similarity:
100
100
46.6
100
N.A.
86.6
N.A.
N.A.
N.A.
46.6
53.3
53.3
N.A.
N.A.
53.3
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
35.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
19
0
0
10
0
10
0
10
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% C
% Asp:
37
0
0
0
0
0
0
0
0
0
0
0
0
10
10
% D
% Glu:
19
0
0
0
64
10
0
10
10
10
10
10
0
10
46
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
0
0
0
0
10
0
0
0
0
0
0
0
10
% G
% His:
0
0
10
0
0
0
0
10
0
10
0
10
0
0
10
% H
% Ile:
0
0
10
0
0
73
0
0
0
0
0
0
28
0
0
% I
% Lys:
0
0
10
0
0
0
0
0
0
10
10
46
0
0
0
% K
% Leu:
19
10
0
10
0
10
0
0
46
0
0
0
73
0
0
% L
% Met:
0
0
0
0
0
0
0
0
37
0
37
0
0
28
10
% M
% Asn:
0
10
10
0
0
0
0
10
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% P
% Gln:
10
0
64
55
28
0
0
28
0
73
28
10
0
28
0
% Q
% Arg:
10
10
0
0
0
0
0
0
0
0
0
19
0
0
0
% R
% Ser:
10
46
0
0
0
0
37
37
0
0
0
10
0
19
10
% S
% Thr:
0
19
0
10
10
0
28
0
0
0
10
0
0
10
0
% T
% Val:
0
0
0
10
0
10
10
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _